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Crospovidone is a synthetic polymer used primarily as a disintegrant in pharmaceutical formulations. It is a cross-linked form of polyvinylpyrrolidone (PVP) and is known for its ability to rapidly absorb water and swell, facilitating the breakdown of tablets and capsules in the digestive tract. This property makes it an essential excipient in the production of solid dosage forms, enhancing bioavailability and ensuring effective drug delivery.
| Chemical structure | Cross-linked polyvinylpyrrolidone |
| Appearance | White to off-white powder |
| Solubility | Insoluble in water, soluble in alcohol |
| Moisture content | Typically less than 5% |
| pH range | 4.0 to 7.0 |
When selecting crospovidone, buyers should consider the specific grade required for their formulation, as different grades may have varying properties and performance characteristics. It's also important to specify the desired moisture content and particle size distribution. Certifications such as USP or EP compliance may be necessary depending on the application, so buyers should confirm these requirements when requesting a quote.
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It is primarily used as a disintegrant in tablets and capsules.
Yes, it is generally recognized as safe and is widely used in the industry.
It should be stored in a cool, dry place away from moisture.
Yes, it is commonly used in nutraceutical formulations.
It absorbs water and swells, helping to break down the tablet or capsule.
Common grades include crospovidone type A and type B.