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Ofloxacin is a synthetic antibiotic belonging to the fluoroquinolone class, primarily used to treat a variety of bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair, thus preventing bacterial growth. Ofloxacin is effective against both Gram-positive and Gram-negative bacteria.
| Chemical formula | C17H20FN3O3 |
| Molecular weight | 361.36 g/mol |
| Purity | Typically ≥ 98% |
| Solubility | Soluble in water and organic solvents |
| Storage conditions | Store in a cool, dry place away from light |
When selecting ofloxacin as an active pharmaceutical ingredient, buyers should consider the required purity levels and specific grades suitable for their formulations. It is important to specify any necessary certifications, such as Good Manufacturing Practice (GMP) compliance, as well as desired quantities. Additionally, understanding the intended application can help in determining the appropriate formulation and dosage forms.
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Ofloxacin is used to treat respiratory tract infections, urinary tract infections, and skin infections, among others.
Ofloxacin may not be suitable for patients with certain conditions, such as those with a history of tendon disorders or hypersensitivity to fluoroquinolones.
Common side effects include nausea, diarrhea, headache, and dizziness.
Ofloxacin is generally not recommended for use in children due to potential risks of joint and tendon damage.
Ofloxacin should be stored in a cool, dry place away from light to maintain its stability.
Dosage varies based on the type of infection but typically ranges from 200 mg to 400 mg per day.